This tutorial focuses on accessing and running R on a High Performance Computing (HPC) system. Since the motivation to switch to an HPC system can be manifold, e.g. due to large memory requirements, GPU usage or increase of computation speed, this training will introduce R users to working in the HPC environment. We also provide an overview of selected Machine Learning methods and show how to work interactively or submit batch jobs. In the end, the participants will have the opportunity to do it all themselves in the Hands-On Session.