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Project lead

MIRACLE

Title: MIRACLE: A Machine learning approach to Identify patients with Resected non-small-cell lung cAnCer with high risk of reLapsE

Duration: 01.04.2022 – 31.03.2025

Research Area: Personalized Medicine

The MIRACLE project focuses on early-stage non-small-cell lung cancer (ES-NSCLC) and seeks to develop a machine learning (ML) algorithm to predict disease-free survival and stratify patients post-surgery. Utilizing a comprehensive approach, the project integrates DNA and RNA sequencing, liquid biopsy, and radiomics features from CT images, alongside clinical-pathological factors, to create a personalized treatment plan. The model will be trained on a cohort of 220 resected ES-NSCLC patients and validated on an independent, prospective cohort of 200 patients.

As the leading partner in algorithm development, our role at ScaDS.AI Dresden/Leipzig includes:

  • integrating the heterogeneous multi-modal data to identify predictive features,
  • developing statistical, machine learning, and deep learning methods for survival analysis,
  • supporting explainability for personalized medicine.
MIRACLE: A Machine learning approach to Identify patients with Resected non-small-cell lung cAnCer with high risk of reLapsE

Aims

MIRACLE aims to identify ES-NSCLC patients at high risk of recurrence after surgery. By developing an ML-based clinical decision support tool, the project is designed to provide personalized treatment options, improve patient management, and thus develop more efficient and ethical treatment strategies.

Problem

Despite the high survival rates after surgery for ES-NSCLC, patient outcomes vary considerably. Current tools have limitations in accurately predicting recurrence risk, underscoring the importance of a comprehensive, personalized approach to patient stratification and treatment.

Technology

The project will utilize a range of advanced ML and data integration technologies, focusing on the analysis of various data types, each anticipated to play an important role within the predictive algorithm. Deep learning and explainable AI (xAI) will also be explored for enhancing prediction accuracy and understanding.

Outlook

The interdisciplinary and multinational effort within the MIRACLE project is expected to advance personalized medicine in lung cancer treatment. This could lead to more precise patient monitoring, targeted adjuvant treatments, and improved outcomes. Moreover, the project aims to add to the ongoing conversation about the use of ethical AI in healthcare, possibly encouraging comparable approaches in other fields of cancer research.

Team

Lead

Photo from Prof. Dr. Erhard Rahm

Prof. Dr. Erhard Rahm

Leipzig University

Department of Computer Science, Database Group, Chair of Databases

Team Members

Photo from Marie-Sophie von Braun

Marie-Sophie von Braun

Leipzig University

Photo from Dr. Jan Ewald

Dr. Jan Ewald

Leipzig University

Photo from Dr. Christian Martin

Dr. Christian Martin

Leipzig University

Partners

The MIRACLE project is managed by a consortium of partners from Italy, Spain, France, and Germany:

funded by:
Gefördert vom Bundesministerium für Bildung und Forschung.
Gefördert vom Freistaat Sachsen.